Bacterial ribosomal RNA detection in cerebrospinal fluid using a viromics approach
oleh: Cormac M. Kinsella, Arthur W. D. Edridge, Ingeborg E. van Zeggeren, Martin Deijs, Diederik van de Beek, Matthijs C. Brouwer, Lia van der Hoek
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2022-12-01 |
Deskripsi
Key points We demonstrate that an unmodified viromic next-generation sequencing methodology effectively detects bacterial pathogen ribosomal RNA in cerebrospinal fluid samples. Sensitivity and specificity displayed pathogen dependent variation. Our finding in principle offers avenues for simultaneous detection of neuropathogenic viruses and bacteria.