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Outcome-based education (OBE) is a kind of advanced education concept, is becoming the mainstream concept of medical education reform. Since “Medical Metabolic Biochemistry” integration module has only a few teaching hours, how to improve the quality of teaching and stimulate students' interest in learning is a real challenge. Based on the OBE education concept, this article aims to summarize the teaching reforms related to learning outcomes, teaching contents and teaching strategies, in order to enhance students' enthusiasm and initiative in learning, so as to improve teaching effectiveness, and also to strengthen the foundation for students to become medical talents that meet the requirements of “Outstanding Talent Education Training Scheme 2.0”.