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Gastric cancer (GC) still represents a relevant health problem in the world for both incidence and mortality rates. Many studies underlined that natural products consumption could reduce GC risk, indicating flavonoids as responsible for the beneficial effects through the modulation of several biological processes, such as the inhibition of cancer antioxidant defense and induction of apoptosis. Since <i>Feijoa sellowiana</i> fruit is known to contain high amounts of flavonoids, among which is flavone, we evaluated the antiproliferative and proapoptotic effects of <i>F. sellowiana</i> acetonic extract on GC cell lines through MTS and Annexin-V FITC assays. Among three GC cell lines tested, SNU-1 results being sensitive to both the <i>F. sellowiana</i> acetonic extract and synthetic flavone, which was used as the reference treatment. Moreover, we evaluated their antioxidant effects, assessing the activity of the antioxidant enzymes supeoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in polymorphonuclear cells. We found a significant increase of their activity after exposure to both <i>F. sellowiana</i> acetonic extract and flavone, supporting the idea that a diet that includes flavone-rich fruits could be of benefit for health. In addition to this antioxidant effect on normal cells, this study indicates, for the first time, an anticancer effect of <i>F. sellowiana</i> acetonic extract in GC cells.