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Berlin’s edema is an acute traumatic maculopathy following ocular blunt trauma, with the major site of injury is photoreceptor outer segments and retinal pigment epithelium (RPE). Optical coherence tomography (OCT) is a useful tool to diagnose and follow microstructural changes in Berlin’s edema. In this report, we present an atypical case of Berlin’s edema that resembled Vogt-Koyanagi-Harada disease. OCT demonstrated multiple neurosensory detachments and giant cystic changes of the outer retina. Fluorescein angiography showed no dye leakage or vascular alterations. The patient was treated with a short period of topical and systemic corticosteroids, and she improved significantly within a few weeks.