Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge
oleh: Shuying Yi, Jing Zhai, Rui Niu, Guangming Zhu, Meixiang Wang, Jianguo Liu, Hua Huang, Yaping Wang, Xiuli Jing, Li Kang, Wengang Song, Yufang Shi, Hua Tang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-09-01 |
Deskripsi
Eosinophils are important mediators of allergic responses, but how they are recruited to the inflamed site is still unclear. Here the authors show that CD103+ cDC1 cells secrete CCL17 and CCL22 for eosinophil recruitment, with this process promoted by CD24−CD11b+ DC2s in the early phase but suppressed by CD24+ cDC2s in the late phase.