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Erythropoiesis and megakaryo-/thrombopoiesis occur in the bone marrow proceeding from common, even bipotent, progenitor cells. Recently, we have shown that protective vaccination accelerates extramedullary hepatic erythroblastosis in response to blood-stage malaria of <i>Plasmodium chabaudi.</i> Here, we investigated whether protective vaccination also accelerates extramedullary hepatic megakaryo-/thrombopoiesis. Female Balb/c mice were twice vaccinated with a non-infectious vaccine before infecting with 10⁶ <i>P. chabaudi</i>-parasitized erythrocytes. Using gene expression microarrays and quantitative real-time PCR, transcripts of genes known to be expressed in the bone marrow by cells of the megakaryo-/thrombocytic lineage were compared in livers of vaccination-protected and unprotected mice on days 0, 1, 4, 8, and 11 <i>p.i.</i> Livers of vaccination-protected mice responded with expression of megakaryo-/thrombocytic genes faster to <i>P. chabaudi</i> than those of unvaccinated mice, evidenced at early patency on day 4 <i>p.i.</i>, when livers exhibited significantly higher levels of malaria-induced transcripts of the genes <i>Selp</i> and <i>Pdgfb</i> (<i>p</i>-values < 0.0001), <i>Gp5</i> (<i>p</i>-value < 0.001), and <i>Fli1</i>, <i>Runx1</i>, <i>Myb</i>, <i>Mpl</i>, <i>Gp1ba</i>, <i>Gp1bb</i>, <i>Gp6</i>, <i>Gp9</i>, <i>Pf4</i>, and <i>Clec1b</i> (<i>p</i>-values < 0.01). Together with additionally analyzed genes known to be related to megakaryopoiesis, our data suggest that protective vaccination accelerates liver-intrinsic megakaryo-/thrombopoiesis in response to blood-stage malaria that presumably contributes to vaccination-induced survival of otherwise lethal blood-stage malaria.