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Objective: The study aimed to explore factors associated with prelabor rupture of membrane (PROM) and mode of delivery of PROM at secondary health care. Methods: It was a retrospective case-control study within a year observational period. Data were collected from medical records at St. Khadijah I Mother and Child Hospital Makassar. Results: There were 4003 samples with 259 cases with PROM. Parity and body mass index (BMI) were factors associated with PROM with p = 0.000 and .032 consecutively; among them, BMI was more prominent than parity with OR = 2.392, and 95% CI = 1.052–5.442. Cesarean section is not associated with PROM, p = .000. Conclusion: Primigravidae and obesity were factors associated with PROM, and BMI was more strongly associated with PROM than parity. PROM is not an indication for cesarean section.