Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
oleh: Christopher D. Scharer, Dillon G. Patterson, Tian Mi, Madeline J. Price, Sakeenah L. Hicks, Jeremy M. Boss
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-08-01 |
Deskripsi
The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell activation, and is coordinated by specific transcriptome programs and proliferation kinetics.