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Pancreatic cancer is a highly malignant tumor of the digestive system. Due to the non-specific clinical symptoms in the early stage, its early diagnosis is very difficult. Almost half of the patients with pancreatic cancer have already developed distant metastases at the time of initial diagnosis. In recent years, organ-specific metastasis of pancreatic cancer has received extensive attention. Patients with lung metastasis of pancreatic cancer have shown significant survival benefits. Compared with other metastatic sites, lung metastasis of pancreatic cancer also shows significant differences in gene expression, tumor microenvironment, tumor stem cells and other aspects. This review summarized the research progress on the mechanism of organ-specific lung metastasis in pancreatic cancer.