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Control of diabetic complications including diabetic retinopathy involves suppression of multiple factors; hence the need for multi-target drugs is appreciable. Anti-inflammatory agents could have a dual effect on cancers, one by suppressing cancer mediating pathways, and by inhibiting aldose reductase enzyme (ALR2), proceeding with ALR2 inhibition related changes in curing cancers. 3D quantitative structure–activity relationship (QSAR) model was built based on the steric fields, hydrophobic and electrostatic fields using Field-Based QSAR which was used to predict the ALR2 inhibiting property of the phytocompounds, Eupalitin-3-O-galactoside, Picroside II, Agnuside and 7-O-Methylwogonin. All anti-inflammatory compounds had IC50 values in nanomolar concentrations, similar to the drug Epalrestat, indicating their capability to be used as multi target drugs in the future.