Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro
oleh: Alona Feldman, Dzmitry Mukha, Itzhak I. Maor, Egor Sedov, Elle Koren, Yahav Yosefzon, Tomer Shlomi, Yaron Fuchs
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-05-01 |
Deskripsi
The sebaceous gland (SG) has been proposed to be replenished by pools of cells, including a population in the SG base, marked by Blimp1. Here, the authors show that Blimp1+ cells can establish an organoid model of the SG, which is regulated by c-Myc and can recapitulate the early stages of acne vulgaris.