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Coronavirus disease 2019 (COVID-19) is the first coronavirus-related global pandemic caused by a novel severe acute respiratory syndrome coronavirus-2, and rapid evolution of the pandemic has resulted in fast-track developments in antivirals, medical management, and vaccination for use to prevent morbidity and mortality. As of today, different institutional treatment protocols and respective national guidelines have been evolved worldwide with team of medical experts and recommended for combinations of antiviral, antibiotics, steroids, and anticoagulants with variable outcomes. Combination therapy has documented better outcome with a significant reduction in mortality and morbidity and considered frontline protocol during this pandemic.