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INTRODUCTION: Laryngopharyngeal reflux (LPR) is a disease that is frequently encountered in the population and affects the quality of life. This disease can cause pathological findings such as polyp, stenosis in the larynx as well as simple symptoms. In addition, respiratory function may be affected due to acid irritation in the larynx and lower respiratory tract. The aim of this study was to investigate the alterations in laryngeal symptoms, signs and respiratory functions after the use of proton pump inhibitors (PPI) in patients with LPR. METHODS: Twenty-four patients were included in this retrospective study. The reflux symptom and finding scores of the patients included in the study were noted. Pulmonary function tests of the patients were recorded. After 3 months of PPI treatment, the values were analyzed and the changes were analyzed. RESULTS: The mean symptom score was 30.33 +- 6.53 to 10.33 +- 4.72; the mean score of the findings decreased from 10.79 +- 3.20 to 4.29 +- 2.78 (p <0.05). In pulmonary function tests, there was no significant change in parameters. DISCUSSION AND CONCLUSION: In patients with LFR, treatment with PPI decreased in symptoms and signs, but no change in pulmonary function tests. More comprehensive studies are needed to determine the effect on respiration.