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Green nanotechnology has significant applications in various biomedical science fields. In this study, green-synthesized silver nanoparticles, prepared by using <i>Catharanthus roseus</i> and <i>Azadirachta indica</i> extracts, were characterized using UV–Vis spectroscopy, dynamic light scattering, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. Silver nanoparticles (Ag NPs) synthesized from leaf extracts of <i>C. roseus</i> and <i>A. indica</i> effectively inhibited the growth of multidrug-resistant (MDR) bacteria isolated from patients with septic wound infections. The maximum bacteriolytic activity of the green-synthesized Ag NPs of <i>C. roseus</i> and <i>A. indica</i> against the MDR bacterium <i>K. Pneumoniae</i> was shown by a zone of inhibition of 19 and 16 mm, respectively. <i>C. roseus</i> Ag NPs exhibited more bacteriolytic activity than <i>A. indica</i> Ag NPs in terms of the zone of inhibition. Moreover, these particles were effective in healing wounds in BALB/c mice. Ag NPs of <i>C. roseus</i> and <i>A. indica</i> enhanced wound healing by 94% ± 1% and 87% ± 1%, respectively. Our data suggest that Ag NPs from <i>C. roseus</i> and <i>A. indicia</i> ameliorate excision wounds, and wound healing could be due to their effective antimicrobial activity against MDR bacteria. Hence, these Ag NPs could be potential therapeutic agents for the treatment of wounds.