Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
oleh: Giulia Parisi, Justin D. Saco, Felix B. Salazar, Jennifer Tsoi, Paige Krystofinski, Cristina Puig-Saus, Ruixue Zhang, Jing Zhou, Gardenia C. Cheung-Lau, Alejandro J. Garcia, Catherine S. Grasso, Richard Tavaré, Siwen Hu-Lieskovan, Sean Mackay, Jonathan Zalevsky, Chantale Bernatchez, Adi Diab, Anna M. Wu, Begoña Comin-Anduix, Deborah Charych, Antoni Ribas
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-01-01 |
Deskripsi
Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.