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In this paper, we applied Differential Transformation Method (DTM) to study micropolar fluid flow and heat transfer through a channel with permeable walls. In order to verify the accuracy and validity of the application of this method to this problem, comparison with numerical method (NUM) is taken into account. Results reveal that DTM is an appropriate method for approximating solutions of the problem while it is smooth and straightforward to implement. The effect of significant parameters such as the Reynolds number, micro rotation/angular velocity and the Peclet number on the stream function, temperature distribution and concentration characteristics of the fluid, is discussed.