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Graphene, with amazing physical and chemical properties, exhibits great potential for next-generation electronic devices. Promising achievements were obtained in recent years. Nevertheless, there are challenges before the industrialization of graphene-based electronic devices (G-EDs), which present opportunities as well. Mass-production of graphene and the growing G-EDs are the major issues. In this perspective, we briefly outline the notable advances in the production of graphene and the development of diverse G-EDs. Then we probe into the critical challenges on the way of G-EDs and provide corresponding strategies. Finally, we give our expectations of G-EDs in the near future.