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<p class="orbitalabstract">A series of novel 6-bromo-2-chloro-3-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-quinoline and its derivatives <strong>(5a-j) </strong>were synthesized in good yields from the intermediates (6-bromo-2-chloro-quinolin-3-yl)-methanol <strong>(2)</strong>, methanesulfonic acid (6-bromo-2-chloroquinolin-3-yl)methyl methanesulfonate <strong>(3) </strong>and 3-azidomethyl-6-bromo-2-chloro-quinoline <strong>(4)</strong>. The synthetic route leading to the title compounds is commenced from commercially available 6-bromo-2-chloro-quinolin-3-carbaldehyde <strong>(1)</strong>. The chemical structures of the newly synthesized compounds were elucidated by their IR, ¹H and ¹³C NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial activity against various microorganisms and antimalarial activity towards <em>P. falciparum</em>.</p><p class="orbitalabstract"> </p><p class="orbitalabstract">DOI: <a href="http://dx.doi.org/10.17807/orbital.v7i3.692">http://dx.doi.org/10.17807/orbital.v7i3.692</a></p><p> </p>