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Stem cells from human exfoliated deciduous teeth (SHEDs) are odontogenic stem cells with strong proliferation ability and multilineage differentiation potential. Due to their easy accessibility and limited ethical concerns, SHEDs have great potential in stem cell therapy. There is still a lack of literature on SHEDs in the treatment of non-oral diseases. This article reviews the latest developments in the use of SHEDs to treat diseases of the nervous, digestive, cardiovascular, urinary, immune, endocrine and respiratory systems. This review will inform the clinical application of SHEDs in non-oral diseases.