Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation
oleh: Fangyuan Wang, Zongpeng Zhang, Yu Chen, Virginie Ratovelomanana-Vidal, Peiyuan Yu, Gen-Qiang Chen, Xumu Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Chiral succinimides are ubiquitous in bioactive compounds. Here, authors report a stereodivergent method for accessing 3,4-disubstituted succinimides, and the origin of stereoselectivity is elucidated by experimental and theoretical investigations.