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A 4-year-old male child, who was diagnosed as congenital cystic adenomatoid malformation of the right lower lobe of the lung, was scheduled for resection of the affected segment. Provision of lung isolation intraoperatively in children is more difficult due to anatomical and physiological differences from an adult. This case represents challenges encountered by the pediatric anesthesiologist to provide intraoperative single lung ventilation in a child, as there are limited options available, and also need for effective postoperative analgesia in the form of thoracic epidural which helped in early recovery.