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Extreme amyloid polymorphism in Staphylococcus aureus virulent PSMα peptides
oleh: Nir Salinas, Jacques-Philippe Colletier, Asher Moshe, Meytal Landau
Format: | Article |
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Diterbitkan: | Nature Portfolio 2018-08-01 |
Deskripsi
The phenol-soluble modulin PSMα3 secreted by Staphylococcus aureus forms cross-α amyloid-like fibrils. Here the authors reveal the amyloid polymorphism of PSMs by presenting the cross-β amyloid fibril structures of the biofilm-associated PSMα1 and PSMα4 and showing that truncated PSMα3 antibacterial peptides form distinct out-of-register β-sheets and a polymorph with a hexameric architecture of β-sheets.