Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
oleh: Stephan Dreschers, Kim Ohl, Michael Lehrke, Julia Möllmann, Bernd Denecke, Ivan Costa, Thomas Vogl, Dorothee Viemann, Johannes Roth, Thorsten Orlikowsky, Klaus Tenbrock
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Neonatal immune responses are known to differ to those of an adult immune response. Here Dreschers and colleagues, compare macrophage populations derived from cord blood or adult peripheral blood and show a metabolic impairment of glycolysis in macrophages derived from cord blood which may impair response to infective scenarios such as sepsis.