Androgen deprivation promotes neuroendocrine differentiation and angiogenesis through CREB-EZH2-TSP1 pathway in prostate cancers
oleh: Yan Zhang, Dayong Zheng, Ting Zhou, Haiping Song, Mohit Hulsurkar, Ning Su, Ying Liu, Zheng Wang, Long Shao, Michael Ittmann, Martin Gleave, Huanxing Han, Feng Xu, Wangjun Liao, Hongbo Wang, Wenliang Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
Neuroendocrine prostate cancers are very difficult to treat and often arise after androgen-deprivation therapy. Here the authors show that ADT activates CREB that acts by increasing EZH2 activity to promote neuroendocrine differentiation in prostate cancer, providing alternative avenues for therapy.