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Background: The endodontic treatment of teeth with immature root has always been a challenge. To achieve a better prognosis, regenerative endodontic treatment may become a treatment trend for teeth with apical periodontitis and immature roots. Methods: Clinical and radiographic data were collected from 38 endodontic treated immature teeth (21 apexification and 17 regeneration). Measure the radiographic outcome by quantifying the apical lesion. Results: There was no statistical difference between the two treatments regarding PAI scores at the 1-, 3-, 6-, and 12-month follow-up (p > 0.05). In addition, different operators and the different stages of root development for both techniques showed no significant statistical difference on the final treatment results. Conclusions: In this study, assessment of the radiographic outcomes indicated that regenerative endodontic treatment were identical to the apexification technique. Keywords: Regenerative endodontic treatment, Pulp revascularization, Apexification, Periapical index (PAI), Radiology