Cytotoxic Metabolites from the Soil-Derived Fungus Exophiala Pisciphila
oleh: Xiu-Kun Lin, Tian-Tian Li, Yu-Yan Zhang, Ming Liu, Hai-Zhou Liu, Cui-Cui Wang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2011-03-01 |
Deskripsi
A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3–4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1–4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher’s method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.