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<i>Pomacea canaliculata</i>, one of the 100 most destructive invasive species in the world, and it is an important intermediate host of <i>Angiostrongylus cantonensis</i>. The molluscicides in current use are an effective method for controlling snails. However, most molluscicides have no slow-release effect and are toxic to nontarget organisms. Thus, these molluscicides cannot be used on a large scale to effectively act on snails. In this study, gelatin, a safe and nontoxic substance, was combined with sustained-release molluscicide and was found to reduce the toxicity of niclosamide to nontarget organisms. We assessed the effects of gelatin and molluscicide in controlling <i>P. canaliculata</i> snails and eggs. The results demonstrated that the niclosamide retention time with 1.0% and 1.5% gelatin sustained-release agents reached 20 days. Additionally, the mortality rate of <i>P. canaliculata</i> and their eggs increased as the concentration of the niclosamide sustained-release agents increased. The adult mortality rate of <i>P. canaliculata</i> reached 50% after the snails were exposed to gelatin with 0.1 mg/L niclosamide for 48 h. The hatching rate of <i>P. canaliculata</i> was only 28.5% of the normal group after the treatment was applied. The sustained-release molluscicide at this concentration was less toxic to zebrafish, which means that this molluscicide can increase the safety of niclosamide to control <i>P. canaliculata</i> in aquatic environments. In this study, we explored the safety of using niclosamide sustained-release agents with gelatin against <i>P. canaliculata</i>. The results suggest that gelatin is an ideal sustained-release agent that can provide a foundation for subsequent improvements in control of <i>P. canaliculata</i>.