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Reno-protective effect of garlic extract against immobilization stress induced changes in rats
по: Syed Kashif Zaidi, Shakeel Ahmed Ansari, Ghulam Md. Ashraf, Mohammad Alam Jafri, Shams Tabrez, Naheed Banu
Формат: | Article |
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Опубликовано: | Wolters Kluwer Medknow Publications 2015-05-01 |
Описание
Objective: To examine immobilization stress-induced antioxidant defense alterations in rat kidney and the antioxidant effects of aqueous garlic extract in pre and post stress extract treatments. Methods: Albino rats were treated with aqueous extract of garlic both before and 6 h of immobilization stress. Pro-oxidant eminence of rat kidney was assessed by determining the levels of glutathione, thiobarbituric acid reactive substances, aspartate aminotransferase, alanine aminotransferase, glucose, uric acid, alkaline phosphatase and antioxidant enzymes activities. Results: In response to 6 h of immobilization stress, a significant rise in the level of kidney enzymes was recorded. However, antioxidant enzyme activities showed a sharp decline. Conclusions: The extract treatment before and after the stress reverted the activities of above mentioned enzymes towards their control values. Hence, garlic extract can be given as nutritional supplement for scavenging the free radicals generated in rat kidney.