Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis
oleh: Urbain Weyemi, Bindu D. Paul, Adele M. Snowman, Parthav Jailwala, Andre Nussenzweig, William M. Bonner, Solomon H. Snyder
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-04-01 |
Deskripsi
H2AX is a histone variant with an essential function in DNA double-strand break repair and genome stability. Here, Weyemi and colleagues show that loss of neuronal H2AX leads to locomotor dysfunction and alteration in oxidative stress response.