ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II
oleh: Seina Ohe, Yuji Kubota, Kiyoshi Yamaguchi, Yusuke Takagi, Junichiro Nashimoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoichi Furukawa, Mutsuhiro Takekawa
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.