Synergistic Pd/Cu-catalyzed enantioselective Csp2–F bond alkylation of fluoro-1,3-dienes with aldimine esters

oleh: Huimin Yu, Qinglong Zhang, Weiwei Zi

Format: Article
Diterbitkan: Nature Portfolio 2022-05-01

Deskripsi

Due to high bond dissociation energies of C(sp2)–F bonds, using fluorinated compounds in C(sp2)–C(sp3) cross-coupling is difficult. Here the authors report a protocol for enantioselective C(sp2)–C(sp3) coupling of dienyl fluorides with aldimine esters, enabled by synergistic copper and palladium catalysis.