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The structural integrity analysis of nuclear power plants (NPPs) is an essential procedure since the age of NPPs is increasing constantly while the number of new NPPs is still limited. Low-cyclic fatigue (LCF) and stress corrosion cracking (SSC) are the two main causes of failure in light-water reactors (LWRs). In the last few decades, many types of research studies have been conducted on these two phenomena separately, but the joint effect of these two mechanisms on the same crack has not been discussed yet though these two loads exist simultaneously in the LWRs. SCC is mainly a combination of the loading, the corrosive medium, and the susceptibility of materials while the LCF depends upon the elements such as compression, moisture, contact, and weld. As it is an attempt to combine SCC and LCF, this research focuses on the joint effect of SCC and LCF loading on crack propagation. The simulations are carried out using extended finite element method (XFEM) separately, for the SCC and LCF, on an identical crack. In the case of SCC, da/dt(mm/sec) is converted into da/dNScc (mm/cycle), and results are combined at the end. It has been observed that the separately calculated results for SCC da/dNScc and LCF da/dNm of crack growth rate are different from those of joint/overall effect,  da/dNom. By applying different SCC loads, the overall crack growth is measured as SCC load becomes the main cause of failure in LWRs in some cases particularly in the presence of residual stresses.