To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
oleh: Manoj B. Menon, Julia Gropengießer, Klaus Ruckdeschel, Matthias Gaestel
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-01-01 |
Deskripsi
Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38MAPK/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.