Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury
oleh: Michael Koeppen, Jae W. Lee, Seong-Wook Seo, Kelley S. Brodsky, Simone Kreth, Ivana V. Yang, Peter M. Buttrick, Tobias Eckle, Holger K. Eltzschig
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-02-01 |
Deskripsi
Myocardial ischemia–reperfusion injury stabilizes the hypoxia-inducible factor HIF2-alpha. Here, the authors show that HIF2-alpha protects the heart from injury via induction of the epidermal growth factor amphiregulin, and that amphiregulin administration is cardioprotective in mice.