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Compelling evidence points to the MET receptor tyrosine kinase as a key player during liver development and regeneration. Recently, a role of MET in the pathophysiology of insulin resistance and obesity is emerging. Herein, we aimed to determine whether MET regulates hepatic insulin sensitivity. To achieve this, mice in which the expression of wild-type MET in hepatocytes is slightly enhanced above endogenous levels (<i>Alb-R26^Met</i> mice) were analyzed to document glucose homeostasis, energy balance, and insulin signaling in hepatocytes. We found that <i>Alb-R26^Met</i> mice exhibited higher body weight and food intake when compared to <i>R26^stopMet</i> control mice. Metabolic analyses revealed that <i>Alb-R26^Met</i> mice presented age-related glucose and pyruvate intolerance in comparison to <i>R26^stopMet</i> controls. Additionally, in <i>Alb-R26^Met</i> mice, high MET levels decreased insulin-induced insulin receptor (IR) and AKT phosphorylation compared to control mice. These results were corroborated in vitro by analyzing IR and AKT phosphorylation in primary mouse hepatocytes from <i>Alb-R26^Met</i> and <i>R26^stopMet</i> mice upon insulin stimulation. Moreover, co-immunoprecipitation assays revealed MET-IR interaction under both basal and insulin stimulation conditions; this effect was enhanced in <i>Alb-R26^Met</i> hepatocytes. Altogether, our results indicate that enhanced MET levels alter hepatic glucose homeostasis, which can be an early event for subsequent liver pathologies.