The transcription factor hepatocyte nuclear factor 4A acts in the intestine to promote white adipose tissue energy storage
oleh: Romain Girard, Sarah Tremblay, Christophe Noll, Stéphanie St-Jean, Christine Jones, Yves Gélinas, Faïza Maloum-Rami, Nathalie Perreault, Mathieu Laplante, André C. Carpentier, François Boudreau
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
HNF4A is a nuclear receptor that regulates liver lipid homeostasis. Here the authors show that HNF4A is not required for intestinal lipid metabolism but controls energy expenditure under diet induced obesity through the fat-induced release of glucose-dependent insulinotropic polypeptide.