Bivalent COVID-19 mRNA booster vaccination (BA.1 or BA.4/BA.5) increases neutralization of matched Omicron variants
oleh: David N. Springer, Michael Bauer, Iris Medits, Jeremy V. Camp, Stephan W. Aberle, Clemens Burtscher, Eva Höltl, Lukas Weseslindtner, Karin Stiasny, Judith H. Aberle
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-08-01 |
Deskripsi
Abstract We report SARS-CoV-2 neutralizing antibody titers in sera of triple-vaccinated individuals who received a booster dose of an original monovalent or a bivalent BA.1- or BA.4/BA.5-adapted vaccine or had a breakthrough infection with Omicron variants BA.1, BA.2 or BA.4/BA.5. A bivalent BA.4/BA.5 booster or Omicron-breakthrough infection induced increased Omicron-neutralization titers compared with the monovalent booster. The XBB.1.5 variant effectively evaded neutralizing-antibody responses elicited by current vaccines and/or infection with previous variants.