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Background: In response to the global COVID-19 pandemic, most countries have taken important measures to control the spread of the virus, such as population confinement and the closure of universities. Objective: The main objective of this study is to evaluate how the situation resulting from COVID-19 has affected the mental health of a group of health sciences students. Material and Methods: This is a cross-sectional, descriptive, observational study with a sample of 160 people, conducted through an online survey of final-year students of dentistry, nursing and medicine at the Faculty of Medicine and Health Sciences of the University of Barcelona. Results: A total of 82.4% of students reported having suffered stress, anxiety and distress due to the pandemic situation, and 83.10% of participants are worried about not knowing when the academic year will restart. Conclusions: Confinement has negatively affected the mental health of students.