Cell-free synthesis of amyloid fibrils with infectious properties and amenable to sub-milligram magic-angle spinning NMR analysis
oleh: Alons Lends, Asen Daskalov, Ansis Maleckis, Aline Delamare, Mélanie Berbon, Axelle Grélard, Estelle Morvan, Jayakrishna Shenoy, Antoine Dutour, James Tolchard, Abdelmajid Noubhani, Marie-France Giraud, Corinne Sanchez, Birgit Habenstein, Gilles Guichard, Guillaume Compain, Kristaps Jaudzems, Sven J. Saupe, Antoine Loquet
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
A method for cell-free synthesis of amyloid fibrils is reported that also allows for solid-state NMR analysis to characterize complex and pathological fibrillary assemblies.