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Abstract We present two cases of Pasteurella multocida (P. multocida) respiratory infection. The first case involves a 62‐year‐old female with abnormal chest shadows, a history of bronchial asthma, and colorectal cancer. Endobronchial ultrasound with a guide sheath (EBUS‐GS) revealed granulomatous changes, and P. multocida was cultured. The second case is a 64‐year‐old female presenting to the emergency department with progressively worsening chest pain and dyspnea, with P. multocida detected from her sputum culture. Treatment with penicillin antibiotics resulted in symptom improvement and normalization of CT findings. These cases indicate the importance of considering P. multocida in respiratory infections, given the patients' history of pet ownership and the nonspecific imaging findings and symptoms. This highlights the necessity for accurate diagnosis and appropriate antibiotic treatment, particularly in cases where animal traumatic exposure is not detected.