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In the title compound, C18H21N3O2S·0.5H2O, the benzene ring makes dihedral angles of 88.59 (6) and 40.74 (8)° with the pyridine ring and the amide group, respectively. The water O atom lies on a twofold axis. In the crystal, the organic molecules and the water molecules are linked via O—H...O hydrogen bonds, while the organic molecules are connected to each other via N—H...O hydrogen bonds, forming a three-dimensional network.