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Late Mesozoic intermediate−felsic volcanics and hypabyssal intrusions are common across the western slope of the Great Xing’an Range (GXAR). Spatiotemporally, these hypabyssal intrusions are closely associated with epithermal Pb−Zn polymetallic deposits. However, few studies have investigated the petrogenesis, contributions and constraints of these Pb−Zn polymetallic mineralization-related intrusions. Therefore, we examine the representative Erdaohezi deposit and show that these mineralization-related hypabyssal intrusions are composed of quartz porphyry and andesite porphyry with concordant zircon U−Pb ages of 160.3 ± 1.4 Ma and 133.9 ± 0.9 Ma, respectively. These intrusions are peraluminous and high-K calc-alkaline or shoshonitic with high Na₂O + K₂O contents, enrichment in large ion lithophile elements (LILEs; e.g., Rb, Th, and U), and depletion in high field strength elements (HFSEs; e.g., Nb, Ta, Zr, and Hf), similar to continental arc intrusions. The zircon εHf(t) values range from 3.1 to 8.0, and the ¹⁷⁶Hf/¹⁷⁷Hf values range from 0.282780 to 0.282886, with Hf-based Mesoproterozoic T_DM2 ages. No differences exist in the Pb isotope ratios among the quartz porphyry, andesite porphyry and ore body sulfide minerals. Detailed elemental and isotopic data imply that the quartz porphyry originated from a mixture of lower crust and newly underplated basaltic crust, while the andesite porphyry formed from the partial melting of Mesoproterozoic lower crust with the minor input of mantle materials. Furthermore, a magmatic−hydrothermal origin is favored for the Pb−Zn polymetallic mineralization in the Erdaohezi deposit. Integrating new and published tectonic evolution data, we suggest that the polymetallic mineralization-related magmatism in the Erdaohezi deposit occurred in a back-arc extensional environment at ~133 Ma in response to the rollback of the Paleo-Pacific Plate.