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<p>Background. The acceptability of ultra low-dose oral contraception (OC) among young females after three and six cycles of treatment was assessed.</p><p>Methods. In the clinical prospective study, carried out in 10 outpatient clinics in Slovenia, 240 healthy women aged 16– 30 years choosing ultra low-dose OC (20 µg ethinyl estradiol and 75 µg gestodene) were included.</p><p>Results. The average age was 20.6 (± 3.5) years. After three cycles (N = 228) there were no changes in body weight or blood pressure; one tenth (9.6%) of women reported irregular bleeding and 3.9% weight gain while other side effects occurred rarely. After three cycles 88.3% of the women initially included continued OC use (5% discontinued the use due to side effects). After six cycles (N = 195) there were no changes in blood pressure; body weight statistically significantly increased for 0.5 kg providing the weight changes during the time were not considered. Fewer women reported side effects (3.6% irregular bleeding, 2.6% weight gain and rarely other side effects). After six cycles 75.0% of the women initially included continued the OC use (7.5% discontinued the use due to the side effects).</p><p>Conclusions. The study has shown good clinical acceptability of ultra low-dose OC by young females.<br /><br /></p>