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In this study, phase-transited lysozyme (PTL) induced Ca10(PO4)6(OH)2 (PTL-HA) coating was applied to the 3D-printed titanium surface for improving bioactivity. The morphology and phase of the coating were analyzed by EDS, SEM, XRD, and XPS, while biocompatibility was investigated in vitro. The observation from SEM showed that a uniform coating with the presence of spheric-like and plate-shaped crystals was covered on the titanium. The main composition of the coating was Ca10(PO4)6(OH)2. More importantly, the in vitro results showed the PTL-HA coating could upregulate the expression of osteogenic-related genes. Therefore, it is considered that the phase-transited lysozyme-induced hydroxyapatite film was a promising, rapid, low-cost, and green route to improve the bioactivity of a bone implant.