Promotion of growth factor signaling as a critical function of β-catenin during HCC progression
oleh: Eunsun Kim, Amanda Lisby, Connie Ma, Nathanael Lo, Ursula Ehmer, Katharina E. Hayer, Emma E. Furth, Patrick Viatour
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-04-01 |
Deskripsi
Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling to promote tumour survival.