mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling
oleh: Yiying Wang, Qiannan Li, Zhiyang Zhang, Kai Peng, Dai-Min Zhang, Qianlu Yang, Anthony G. Passerini, Scott I. Simon, ChongXiu Sun
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-07-01 |
Deskripsi
The endothelium-specific inhibition of either of mammalian target of rapamycin (mTOR) complexes impairs endothelial-dependent vasodilatation (EDD), accompanied by decreased nitric oxide bioavailability in both human and mice endothelial cells.