Activation of neural lineage networks and ARHGEF2 in enzalutamide-resistant and neuroendocrine prostate cancer and association with patient outcomes
oleh: Shu Ning, Jinge Zhao, Alan P. Lombard, Leandro S. D’Abronzo, Amy R. Leslie, Masuda Sharifi, Wei Lou, Chengfei Liu, Joy C. Yang, Christopher P. Evans, Eva Corey, Hong-Wu Chen, Aiming Yu, Paramita M. Ghosh, Allen C. Gao
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-09-01 |
Deskripsi
Ning et al. report expression of a neural lineage gene signature in enzalutamide-resistant prostate cancer cells and datasets from patients with neuroendocrine prostate cancer. One of these genes, ARHGEF2, is associated with poor overall and disease-free survival in patients with castration-resistant disease and supports cell viability in vitro.