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Bernard Stiegler has undertaken a renovation of philosophical concepts by taking account of thermodynamic and informational entropy and the counter-entropic tendencies that struggle against them. Such a renovation brings the question of locality into new focus, given the localized character of all such struggles, where this is distributed at various scales from the cellular to the biospheric and technospheric. This paper pursues this question of locality in two parts: the first finds resources for such a renovation in Empedocles, and notes how these were repressed by Aristotle but resurrected by Sigmund Freud and Friedrich Nietzsche; the second stages a confrontation between Stiegler and Peter Sloterdijk, asking under what conditions the latter’s immunological spherology could be brought into Stiegler’s project, which we place under the umbrella of what we are proposing to call metacosmics.