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Background: Persistent hysterical hiccups are not a usual presentation in medicine. Both, the rational of choosing a specific modality of intervention and the possible biological mechanism behind hysterical hiccups are often ambiguous. Case description: A 37-year old married female with history of hiccups since the past two weeks was referred to the Department of Psychiatry for further management. She was extensively evaluated for other medical causes for hiccups and later diagnosed as a case of persistent hysterical hiccups. She improved with chlorpromazine which is an antidopaminergic drug. Discussion: This case responded well with antidopaminergic medication. The case suggests the possible role of dopamine in the biological mechanism of a specific clinical category of persistent hysterical hiccups. Conclusion: Our case demonstrates the use of chlorpromazine to effectively treat hiccups of psychogenic origin.