Coumarinolignans with Reactive Oxygen Species (ROS) and NF-κB Inhibitory Activities from the Roots of <i>Waltheria indica</i>
oleh: Feifei Liu, Sudipta Mallick, Timothy J. O’Donnell, Ruxianguli Rouzimaimaiti, Yuheng Luo, Rui Sun, Marisa Wall, Supakit Wongwiwatthananukit, Abhijit Date, Dane Kaohelani Silva, Philip G. Williams, Leng Chee Chang
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2022-05-01 |
Deskripsi
Seven new coumarinolignans, walthindicins A–F (<b>1a</b>, <b>1b</b>, <b>2</b>–<b>5</b>, <b>7</b>), along with five known analogs (<b>6</b>, <b>8</b>–<b>11</b>), were isolated from the roots of <i>Waltheria indica</i>. The structures of the new compounds are determined by detailed nuclear magnetic resonance (NMR), circular dichroism (CD) with extensive computational support, and mass spectroscopic data interpretation. Compounds were tested for their antioxidant activity in Human Cervical Cancer cells (HeLa cells). Compounds <b>1a</b> and <b>6</b> showed higher reactive oxygen species (ROS) inhibitory activity at 20 μg/mL when compared with other natural compound-based antioxidants such as ascorbic acid. Considering the role of ROS in nuclear-factor kappa B (NF-κB) activation, compounds <b>1a</b> and <b>6</b> were evaluated for NF-κB inhibitory activity and showed a concentration-dependent inhibition in Human Embryonic Kidney 293 cells (Luc-HEK-293).